Flights Rome → San Francisco — September 21, 2026

One way · Economy · 1 adult · price per person

The cheapest itinerary observed for Monday, September 21, 2026 on the Rome–San Francisco route: 2 stops itinerary (3 flights) via Barcelona (BCN) and Lisbon (LIS), from Rome Fiumicino (FCO) to San Francisco International (SFO), first flight Ryanair FR6986, departs 6:25 AM, arrives 1:35 PM the next day, total travel time 40h 10m including layovers, flight time 16h 25m (layovers excluded), $569 per person. Fare as listed by Aviasales: carry-on bag not included (personal item only), checked bag not included, changes not allowed, non-refundable. Price found in an Aviasales search on September 7, 2026 and read by AirSource on September 10, 2026, 20:48 UTC: it is not guaranteed and is confirmed on Aviasales at booking time. The cheapest direct flight observed: ITA Airways AZ640, from Rome Fiumicino (FCO) to San Francisco International (SFO), departs 9:10 AM, arrives 1:15 PM, direct, 13h 5m, $758 per person. Fare as listed by Aviasales: carry-on bag not included (personal item only), checked bag not included, changes not allowed, non-refundable.